Long-Term Optical Access to the Brain

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See-Shells

The SeeShells are transparent polymer cranial windows mimicking the shape and contour of the skull and provide optical access to most of the dorsal cortex of mice:

  • Imaging area of >45 mm2

  • Biocompatible transparent polymer (PET)

  • Fully tested for high resolution 2P and 1P imaging

  • Titanium headpost of stable headfixation

  • Longterm stability (>1year)

  • Protective cap for use when not imaging

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See-Shells in action

Two-photon imaging during wake head-fixation

Two-photo cortical column imaging

  1. L. Ghanbari, R. E. Carter, M. L. Rynes, J. Dominguez, G. Chen, A. Naik, J. Hu, M. A. K. Sagar, L. Haltom, N. Mossazghi, M. M. Gray, S. L. West, K. W. Eliceiri, T. J. Ebner, S. B. Kodandaramaiah, ‘Cortex-wide neural interfacing via transparent polymer skulls’, Nature Communications’, 2019

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