Wide-field cortical imaging

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mini-mScope

Objective Biotechnology’s mini-mScope enables whole brain imaging in freely behaving rodents:

  • Whole dorsal cortex mesoscale imaging

  • 8 x 10 mm field of view

  • 17-35 μm imaging resolution

  • High sensitivity CMOS sensor

  • Weight < 4g

  • Magnetic clamping for instantaneous stress-free docking

  • Robust motion free imaging in a wide range of behaviors

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mini-mScope in action

Neural activity

Open-field behavior of mouse bearing mini-mScope

Publications:

Patent:

M. L. Rynes*, D. Surinach*, S. Linn, M. Laroque, V. Rajendran, J. Dominguez, O. Hadjistamoulou, Z. S. Navabi, L. Ghanbari, G. W. Johnson, M. Nazari, M. Mohajerani, S. B. Kodandaramaiah, ‘Miniaturized head-mounted microscope for whole-cortex mesoscale imaging in freely behaving mice’, Nature Methods 2021 *Equal Contribution

Suhasa Kodandaramaiah, Leila Ghanbari, Daniel Sousa Schulman, Michael Cary McAlpine, ‘Systems and methods for multimodal neural sensing’, US Patent, 2021/0169334 A1, Jun . 10 , 2021

Papers using mini-mScope:

  1. Haley SP, Surinach DA, Nietz AK, et al. ‘Cortex-wide characterization of decision-making neural dynamics during spatial navigation.’ Nature Communications. 2026.

  2. Daniel Surinach,* Mathew L Rynes,* Kapil Saxena, Eunsong Ko, A David Redish, Suhasa B Kodandaramaiah, ‘Distinct mesoscale cortical dynamics encode search strategies during spatial navigation’, bioRxiv, March 2023, *Equal Contribution

  3. Kodandaramaiah S, Rynes ML, Surinach DA, et al. ‘Mesoscale Calcium (Ca²⁺) Imaging in Freely Behaving Mice.’ Neuromethods. 2025;214:75–100

  4. Niemeyer et al., 2025. ‘Seizure network characterization by functional connectivity mapping and manipulation.’ Neurophotonics, 12(Suppl 1), S14605. DOI: 10.1117/1.NPh.12.S1.S14605

  5. Oladepo I, Saxena K, Surinach D, Lehman M, Kodandaramaiah SB. ‘Computer vision–guided open-source active commutator for neural imaging in freely behaving animals. Neurophotonics.’ 2024;11(3):034312. DOI: 10.1117/1.NPh.11.3.03431